I struggled for 2 hours with a Windows 2008 SP 2 machine that refused to do anything other than presenting an 80072efd error when asked to perform a Windows Update check. It worked two months ago. Nothing has changed to the best of my knowledge. I tried all the MS KB's. Nothing helped.
So when I merely changed Update Frequency to Install Updates Automatically and checked again, it suddenly started working. WTF?
PS: Seems like this was just a fluke. The real problem was that even though I removed the old (invalid) proxy server definition from IE, it still lingered in
Sometimes I need to fiddle with a registry setting normally under HKEYCURRENTUSER, but that points to your own hive. When you need to change another user's registry whilst being logged in on a terminal server, you cannot load the hive file ntuser.dat as it is already loaded. For that issue the following command in cmd.exe:
wmic useraccount get name,sid
Then use the SID to locate the user's hive under HKEY_USERS.

Just received a business requirement document from a multi billion dollar company... Guess this "Used [sic] Case" is feeling tired even though it is only number 1!

According to Microsoft, it is a supported operation to upgrade a Windows 2008 R2 Domain Controller in place to Windows 2012 Standard (GUI to GUI). But let me warn you - this will most likely fail. I have tried upgrading and after working around some small issues (such as incompatible Anti Virus and some S3 Device Cap driver issue, I finally had no warnings left for the upgrade pre-flight check. It started the upgrade, and rebooted a couple of times. However it never got past "Getting Ready" with the spinning circle. Luckily I could roll back...
In the end to get from Windows Server 2008 R2 PDC with Exchange 2010 to Windows Server 2012 with Exchange 2013 I did the below: